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[Amitriptyline and imipramine poisoning]

H Paul, W Ehrenthal, W Wahlen

    Padiatrie Und Padologie
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Severe poisoning from tricyclic antidepressants (Amitriptylin, Imipramin) in children can cause serious cardiovascular and neurological symptoms. Physostigmine may be a useful antidote in severe cases, alongside supportive care.

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    Area of Science:

    • Toxicology
    • Pediatrics
    • Pharmacology

    Background:

    • Tricyclic antidepressants (TCAs) are commonly prescribed for various conditions, including enuresis in children.
    • Overdose of TCAs can lead to significant toxicity, particularly in pediatric patients.
    • Understanding the clinical manifestations and management of TCA poisoning is crucial for pediatric emergency care.

    Observation:

    • Two pediatric cases of severe poisoning due to Amitriptyline and Imipramine are presented.
    • Patients exhibited characteristic anticholinergic (atropine-like) symptoms.
    • Cardiovascular and neurological complications were prominent features in both cases.

    Findings:

    • Both children presented with a severe clinical picture consistent with tricyclic antidepressant toxicity.

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  • Supportive management was initiated for both patients.
  • Physostigmine was administered as an antidote in one of the cases, with observed effects.

    • Implications:

    • This report highlights the potential severity of tricyclic antidepressant poisoning in children.
    • Physostigmine may be a viable antidote option for managing severe TCA overdose in pediatric populations.
    • The findings underscore the importance of considering alternative treatments for childhood enuresis to minimize risks associated with TCA use.