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Platelet monoamine oxidase in families of chronic schizophrenics
Abstract:
Many reports have described low platelet monoamine oxidase (MAO) activity in chronic schizophrenia. In an effort to determine whether this low activity is genetically controlled, the authors studied platelet MAO activity in the first-degree relatives of 12 chronic schizophrenics (who themselves had low platelet MAO activity). The 29 relatives had significantly lower mean Vmax and Km values than a control group. The authors postulate that the low platelet MAO activity among chronic schizophrenics may be a genetic marker for vulnerability to chronic schizophrenia.
Insights
Low platelet monoamine oxidase (MAO) activity is observed in chronic schizophrenia. This study suggests low MAO activity in relatives indicates a potential genetic marker for schizophrenia vulnerability.
Area of Science:
- Neuroscience
- Psychiatry
- Genetics
Background:
- Chronic schizophrenia is frequently associated with reduced platelet monoamine oxidase (MAO) activity.
- The genetic basis for this reduced MAO activity remains unclear.
Purpose of the Study:
- To investigate if low platelet monoamine oxidase (MAO) activity in chronic schizophrenia patients is genetically determined.
- To assess platelet MAO activity in first-degree relatives of individuals with chronic schizophrenia and low MAO activity.
Main Methods:
- Platelet monoamine oxidase (MAO) activity was measured in 12 individuals with chronic schizophrenia and low MAO activity.
- Platelet MAO activity was also assessed in 29 of their first-degree relatives.
- Enzyme kinetic parameters (Vmax and Km) were compared between the relatives and a control group.
Main Results:
- First-degree relatives of chronic schizophrenics exhibited significantly lower mean Vmax and Km values compared to a control group.
- This finding suggests a familial aggregation of reduced platelet MAO activity.
Conclusions:
- Low platelet monoamine oxidase (MAO) activity may serve as a genetic marker for vulnerability to chronic schizophrenia.
- Further research is warranted to explore the genetic underpinnings of MAO activity in schizophrenia.