Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperthermia in cancer therapy

K H Luk, R M Hulse, T L Phillips

    The Western Journal of Medicine
    |March 1, 1980
    PubMed
    Summary

    Moderate hyperthermia (42-43°C) selectively destroys tumor cells without harming normal tissues. Combining hyperthermia with radiation therapy shows promise for improved cancer treatment outcomes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Update on the Hong Kong Reference Framework for Hypertension Care for Adults in Primary Care Settings-review of evidence on the definition of high blood pressure and goal of therapy.

    Hong Kong medical journal = Xianggang yi xue za zhi·2019
    Same author

    Prevalence and associated comorbidities of moderate to severe chronic renal impairment in Chinese nursing home older adults.

    Journal of the American Medical Directors Association·2012
    Same author

    A noninvasive eye fixation monitoring system for CyberKnife radiotherapy of choroidal and orbital tumors.

    Medical physics·2009
    Same author

    Economic evaluation of interventions to reduce road traffic injuries--a review of the literature with applications to low and middle-income countries.

    Asia-Pacific journal of public health·2008
    Same author

    Peripheral dose in ocular treatments with CyberKnife and Gamma Knife radiosurgery compared to proton radiotherapy.

    Physics in medicine and biology·2007
    Same author

    Phase III trial of accelerated hyperfractionation with or without difluromethylornithine (DFMO) versus standard fractionated radiotherapy with or without DFMO for newly diagnosed patients with glioblastoma multiforme.

    International journal of radiation oncology, biology, physics·2001

    Area of Science:

    • Oncology
    • Biophysics

    Background:

    • Malignant cells show therapeutic responses to elevated temperatures.
    • Moderate hyperthermia (42-43°C) can selectively destroy tumor cells in vivo.
    • Heat-induced cell killing is independent of oxygen levels.

    Purpose of the Study:

    • Investigate the differential thermal sensitivity of malignant cells.
    • Enhance tumor control in patients resistant to conventional therapies.
    • Evaluate hyperthermia as an adjunct to radiotherapy.

    Main Methods:

    • In vivo studies of moderate hyperthermia.
    • Clinical trial combining hyperthermia and radiation therapy.
    • Analysis of thermal damage sensitivity in S-phase cells.

    Main Results:

    • Tumor eradication achieved without normal tissue morbidity.
    • Thermal sensitivity of S-phase cells complements radiation response.
    • Preliminary clinical trial indicates increased local objective responses with combined treatment.

    Conclusions:

    • Hyperthermia is a promising adjunct to radiotherapy.
    • Combining hyperthermia and radiation therapy improves tumor control.
    • Further research is warranted for refractory tumors.

    Related Experiment Videos