Effect of alpha, alpha'-dipyridyle on the testicular parenchyma of the rat

Treatment with an iron-chelating substance (alpha, alpha'-dipyridyle) provokes alterations in the seminiferous tubules and interstitial tissue of rat testicular parenchyma. The action of the drug seems to be dependent neither on the dose nor on the duration of the treatment. The effects of the drug appear in the testicular parenchyma according to a centripetal course either in the whole gonad or in the tubule. Because the alterations of the testicular parenchyma occur at the first treatments the reaction of the tissue cannot be ascribed to an intoxication effect of the drug. The interstitital cells of the testicular parenchyma show greater resistance to the action of dipyridyle than the seminal epithelial cells.