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Studies on Cob (Colton) antigen and anti-Cob
Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology
|February 1, 1980
Insights
The Cob antigen is fully developed at birth, with no gene dosage effect observed. Its frequency in Danes matches other Caucasian populations, and the antibody is IgG without complement fixation.
Area of Science:
- Immunogenetics
- Blood Group Serology
Background:
- The Cob blood group antigen is rare.
- Understanding its expression and prevalence is important for transfusion medicine.
Purpose of the Study:
- To characterize the Cob antigen's expression at birth.
- To investigate gene dosage effects for Cob.
- To determine the frequency of Cob in the Danish population.
Main Methods:
- Utilized a specific anti-Cob antiserum for antigen detection.
- Analyzed blood samples from newborns and the general population.
- Determined antibody class and complement-fixing ability.
Main Results:
- Cob antigen expression is fully developed at birth.
- No evidence of gene dosage effect was found.
- The frequency of Cob-positive individuals in Denmark is 7.8%, similar to other Caucasian groups.
- The anti-Cob antibody is of the IgG class and does not fix complement.
Conclusions:
- The Cob antigen is reliably expressed from birth.
- The prevalence of Cob in Danes is consistent with other Caucasian populations.
- The anti-Cob antibody's characteristics are defined.
Abstract:
Using a reliable and strong reacting antiserum of the rare anti-Cob specificity, it was shown that the Cob antigen was fully developed at birth. Gene dosage effect could not be demonstrated. The frequency of Co(b+) persons in the Danish population (7.8%) was found not to differ from other Caucasian populations. The antibody belonged to immunoglobulin class IgG without ability of fixing complement in vitro.