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Spinal vasomotor reflex and Cushing response

A Pásztor, E Pásztor

    Acta Neurochirurgica
    |January 1, 1980
    PubMed
    Summary

    Isolated intraspinal hypertension triggers a spinal vasomotor reflex (SVR) similar to the Cushing response (CR). SVR intensity correlates with spinal cord length, suggesting spinal vegetative structures contribute to the CR during increased intracranial pressure.

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    Area of Science:

    • Neuroscience
    • Physiology
    • Cardiovascular Research

    Background:

    • The Cushing response (CR) is a hallmark of increased intracranial pressure (ICP).
    • The precise mechanisms and contributing factors to the CR are still under investigation.
    • Spinal vasomotor reflexes (SVR) play a role in regulating blood pressure.

    Purpose of the Study:

    • To investigate the role of isolated intraspinal hypertension in evoking a spinal vasomotor reflex.
    • To determine the factors influencing the intensity of the spinal vasomotor reflex.
    • To elucidate the contribution of spinal vegetative structures to the Cushing response.

    Main Methods:

    • Induction of isolated intraspinal hypertension in a model system.
    • Measurement of spinal vasomotor reflex (SVR) intensity.
    • Correlation analysis between SVR intensity and spinal cord characteristics.

    Main Results:

    • Isolated intraspinal hypertension successfully evoked a spinal vasomotor reflex.
    • The intensity of the SVR was found to be dependent on the length of the isolated spinal cord.
    • Vasopressor effects suggest potential ischemia of spinal vegetative structures.

    Conclusions:

    • A spinal vasomotor reflex, mimicking the Cushing response, can be elicited by intraspinal hypertension.
    • Spinal vegetative structures contribute to the overall Cushing response, particularly when craniospinal connections are intact.
    • Ischemia of spinal vasomotor structures may underlie the vasopressor effects observed.

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