Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myospherulosis--further observations

T M Wheeler, M H McGavran

    American Journal of Clinical Pathology
    |May 1, 1980
    PubMed
    Summary

    Myospherulosis is linked to altered red blood cells (erythrocytes). Researchers created myospherules in vitro using common ointment ingredients like petrolatum and lanolin, and even human fat.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Pathogenesis of Psittacosis: Serial Studies on Rhesus Monkeys Exposed to a Small-Particle Aerosol of the Borg Strain.

    The American journal of pathology·2009
    Same author

    Morphologic and Immunohistochemical Studies of the Pathogenesis of Infection and Antibody Formation Subsequent to Vaccination of Macaca irus with an Attenuated Strain of Pasteurella tularensis: I. Intracutaneous Vaccination.

    The American journal of pathology·2009
    Same author

    Morphologic and Immunohistochemical Studies of the Pathogenesis of Infection and Antibody Formation Subsequent to Vaccination of Macaca irus With an Attenuated Strain of Pasteurella tularensis: II. Aerogenic Vaccination.

    The American journal of pathology·2009
    Same author

    Rift Valley Fever Virus Hepatitis: Light and Electron Microscopic Studies in the Mouse.

    The American journal of pathology·2009
    Same author

    Ribonuclear foci at the neuromuscular junction in myotonic dystrophy type 1.

    Neuromuscular disorders : NMD·2007
    Same author

    The emerging role of the PI3-K-Akt pathway in prostate cancer progression.

    Prostate cancer and prostatic diseases·2005

    Area of Science:

    • Biochemistry
    • Cell Biology
    • Dermatology

    Background:

    • Myospherulosis, a condition characterized by the presence of myospherules, has recently been identified as originating from altered erythrocytes.
    • Previous research demonstrated the in vivo and in vitro production of myospherules using a petrolatum-based tetracycline antibiotic ointment (Achromycin).

    Purpose of the Study:

    • To investigate the in vitro production of myospherules using individual components of a petrolatum-based antibiotic ointment vehicle.
    • To determine if human fat can also induce myospherule formation in vitro.

    Main Methods:

    • In vitro experiments were conducted using lanolin and petrolatum, the primary components of the Achromycin ointment vehicle.
    • Human adipose tissue (fat) was utilized as a substrate for in vitro myospherule production analysis.

    Main Results:

    • Myospherules were successfully produced in vitro using both lanolin and petrolatum.
    • The study confirmed that human fat can also induce the formation of myospherules in an in vitro setting.

    Conclusions:

    • The findings indicate that the vehicle components of certain antibiotic ointments, specifically lanolin and petrolatum, can independently induce myospherule formation.
    • This research expands the understanding of myospherule origins, suggesting potential roles for lipid-based substances and altered erythrocytes in their development.

    Related Experiment Videos