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Transient 'lazy-leukocyte' syndrome during infancy
American Journal of Diseases of Children (1960)
|May 1, 1980
Summary
This study describes a male infant with transient severe neutropenia and defective neutrophil mobility, experiencing recurrent infections. The condition resolved by 16 months, suggesting a transient "lazy-leukocyte" syndrome.
Area of Science:
- Immunology
- Pediatric Hematology
Background:
- Neutropenia, a low neutrophil count, increases infection risk.
- Defective neutrophil function can impair immune response.
Observation:
- A male infant presented with severe neutropenia and impaired neutrophil mobility.
- Recurrent upper respiratory infections were noted, responding to antibiotics.
Findings:
- Neutrophil counts and mobility defects were transient, normalizing by 16 months.
- No ultrastructural neutrophil abnormalities or impaired phagocytosis/bactericidal activity were observed.
- Bone marrow examination was normal.
Implications:
- The findings suggest a transient form of "lazy-leukocyte" syndrome in infants.
- This highlights the importance of monitoring neutrophil function in recurrent infections.