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[Buprenorphine. Haemodynamic study (author's transl)]

E Melon, A Lienhart, P Viars

    Anesthesie, Analgesie, Reanimation
    |January 1, 1980
    PubMed
    Summary
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    Intravenous buprenorphine (3 microgram/kg) was studied in nine subjects. The opioid analgesic demonstrated mild hemodynamic effects, including reduced heart rate and blood pressure.

    Area of Science:

    • Anesthesiology
    • Pharmacology

    Context:

    • Intravenous buprenorphine is an opioid analgesic.
    • Hemodynamic monitoring is crucial in anesthesia and critical care.

    Purpose:

    • To investigate the hemodynamic effects of a specific dose of intravenous buprenorphine (3 microgram/kg).

    Summary:

    • Nine subjects undergoing controlled ventilation were studied using radial arterial and Swan-Ganz catheters.
    • Results showed a statistically significant decrease in heart rate, mean arterial blood pressure, and cardiac index post-buprenorphine administration.
    • These hemodynamic changes were observed to be mild and transient.

    Impact:

    • Provides data on the cardiovascular profile of intravenous buprenorphine.

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  • Informs clinical decisions regarding its use in patients requiring hemodynamic monitoring.