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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
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Decreased Fc and complement receptors on the phagocytes of asthmatic children

K H Hsieh

    Annals of Allergy
    |May 1, 1980
    PubMed

    Insights

    Asthmatic children show reduced immune cell receptors for immunoglobulins and complement. Allergen exposure further decreases these receptors on polymorphonuclear cells, impacting immune response in asthma.

    Area of Science:

    • Immunology
    • Allergy Research
    • Cell Biology

    Background:

    • Immune cell surface receptors play a crucial role in host defense.
    • Polymorphonuclear (PMN) and mononuclear phagocytes utilize Fc and complement receptors for immune functions.
    • Dysregulation of these receptors is implicated in various inflammatory conditions, including asthma.

    Purpose of the Study:

    • To investigate the expression of Fc and complement receptors on immune cells in asthmatic children.
    • To compare receptor levels between asthmatic children and healthy controls.
    • To assess the impact of allergen exposure on these receptors in allergic individuals.

    Main Methods:

    • Studied Fc and complement receptors on PMN and mononuclear phagocytes.
    • Utilized erythrocyte-antibody (EA) complexes for Fc receptor detection.
    • Employed erythrocyte-antibody-complement (EAC) complexes for complement receptor detection.
    • Compared receptor percentages in 57 asthmatic children and 23 normal controls.
    • Assessed receptor changes after in vitro allergen incubation in allergic patients.

    Main Results:

    • Asthmatic children exhibited significantly lower mean percentages of PMN and monocytes with Fc and complement receptors compared to normal controls.
    • In allergic patients, the number of PMN with Fc and complement receptors significantly decreased following allergen incubation.
    • These findings suggest a potential impairment in immune cell receptor function in pediatric asthma.

    Conclusions:

    • Pediatric asthma is associated with reduced Fc and complement receptor expression on key immune cells.
    • Allergen challenge exacerbates this reduction, highlighting a potential mechanism in allergic asthma.
    • Further research is warranted to explore therapeutic strategies targeting these receptor pathways.

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