Role of dopamine receptors in vesicourethral function. A urodynamic study with dopamine receptor antagonist...

The effect of intravenous administration of 20 mg metoclopramide, a dopamine receptor antagonist upon cystometry, urethral pressure profile and external urethral sphincter electromyography (EMG) was investigated in 10 patients with neurogenic bladder dysfunction. No significant change was noticed in detrusor reflex activity or in peak urethral pressure. This suggests that dopamine receptors are not important in vesicourethral function. The increase in sphincter EMG activity observed was probably due to the cholinergic effect of metoclopramide.