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Effects of ocular decongestants
Archives of Ophthalmology (Chicago, Ill. : 1960)
|May 1, 1980
Summary
This study compared eight ocular decongestants. 0.02% naphazoline hydrochloride was found to be the most effective vasoconstrictor, outperforming other nonprescription options.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Ocular decongestants are widely used for eye redness.
- Their vasoconstrictive effectiveness varies.
- Histamine-induced erythema is a common model for testing efficacy.
Purpose of the Study:
- To compare the vasoconstrictive effectiveness of eight commercial ocular decongestants.
- To evaluate their ability to counteract and prevent recurrence of histamine-induced eye redness.
Main Methods:
- Human subjects (n=6) participated in seven sessions.
- Ocular decongestants were tested for vasoconstrictive effect against histamine-induced erythema.
- Rechallenge after one hour assessed sustained effectiveness.
Main Results:
- All tested vasoconstrictors demonstrated effectiveness.
- 0.02% naphazoline hydrochloride showed comparable vasoconstrictive effect to other preparations.
- This concentration of naphazoline was significantly more effective than other nonprescription decongestants as a group.
Conclusions:
- 0.02% naphazoline hydrochloride is a highly effective ocular vasoconstrictor.
- It offers superior efficacy compared to other nonprescription decongestants tested.
- This concentration provides significant vasoconstriction, comparable to higher concentrations.