Related Experiment Video
Updated: Sep 21, 2026

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
Published on: December 3, 2020
A model solution for intestinal absorption of warfarin. A drug with non-linear distribution pharmacokinetics in the
Abstract:
A non-linear multicompartment model with saturation kinetics of binding to plasma and interstitial fluid proteins and with non-saturable binding to tissues has been applied to the absorption of warfarin (8 mg/kg of warfarin sodium) from the rat small intestine in situ. The absorption was best described with two pathways, one into plasma and the other instantaneously into the interstitial fluid. According to the results from the best computerized curve fitting, absorption is rapid, the apparent absorption rate constant being 0.258 min -1. At hypothetical zero time 0.253 of the dose (1.0) would be located in plasma, 0.597 in interstitial fluid 0.150 in tissues.
More Related Videos
08:28Microsurgical Skills of Establishing Permanent Jugular Vein Cannulation in Rats for Serial Blood Sampling of Orally Administered Drug
Published on: December 14, 2021
07:56A Comprehensive Rat Model For Assessing Hepatic Transport Pathways Through Simultaneous Lymphatic And Blood Vascular Sampling
Published on: May 15, 2026
Related Concept Videos
Compartment Models: Two-Compartment Model
Methods for Studying Drug Absorption: In situ
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
One-Compartment Open Model for IV Bolus Administration: Estimation of Elimination Rate Constant, Half-Life and Volume of Distribution
One-Compartment Open Model for Extravascular Administration: First-Order Absorption Model
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance
A recent model describes pravastatin's hepatobiliary excretion, mediated...