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Brain and behavioral asymmetries for spatial preference in rats

G F Sherman, J A Garbanati, G D Rosen

    Brain Research
    |June 16, 1980
    PubMed
    Summary

    Early handling in rats influences brain asymmetry and spatial preferences. Intact handled rats show leftward bias, suggesting right hemisphere control, while non-handled rats exhibit balanced asymmetry for behavioral symmetry.

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    Area of Science:

    • Neuroscience
    • Behavioral Neuroscience
    • Developmental Neuroscience

    Background:

    • Early life experiences, such as handling, can significantly impact brain development and behavior.
    • Brain asymmetry is known to underlie various cognitive functions, including spatial navigation.

    Purpose of the Study:

    • To investigate the role of early handling and brain asymmetry in spatial preference in adult rats.
    • To determine how neocortical ablations affect behavioral symmetry in handled and non-handled rats.

    Main Methods:

    • Rats were either handled or non-handled from birth to weaning.
    • Adult male rats underwent neocortical ablation (right or left), sham operation, or no surgery.
    • Open field tests were conducted to record the initial direction of movement (right or left).

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    Main Results:

    • Non-handled rats with intact brains showed no significant spatial preference.
    • Non-handled rats with left hemisphere ablations exhibited ipsilateral bias compared to those with right hemisphere ablations.
    • Intact handled rats displayed a significant preference for leftward movement.

    Conclusions:

    • Behavioral symmetry in non-handled rats results from balanced brain asymmetry, with the right hemisphere promoting leftward movement and the left hemisphere inhibiting it.
    • Early handling in rats leads to a right-hemisphere-controlled spatial preference for leftward movement.