Endoscopic diagnosis of immunoproliferative small intestinal disease (IPSID)

Six patients with immunoproliferative small intestinal disease (IPSID), were examined endoscopically. The disease was found to involve the duodenum and jejunum and was characterized by the loss of the mucosal circular folds, a thickened cobblestone appearance of the mucosa and multiple sessile polyps. Ulceration of the mucosa was seen in one patient. A large ulcerated mass was seen in the third part of the duodenum in one patient.