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D(-)Lactic acid--a physiological isomer in the rat
Experientia
|May 15, 1980
Summary
D(-)Lactate is produced alongside L(+)lactate in rat stomachs. This D(-)Lactate is absorbed into the bloodstream, establishing it as a physiological isomer in rats.
Area of Science:
- Biochemistry
- Physiology
- Animal Science
Background:
- Lactate isomers, D(-)lactate and L(+)lactate, are key metabolic intermediates.
- The production and physiological role of D(-)lactate in mammalian stomachs are not well understood.
Purpose of the Study:
- To investigate the presence and significance of D(-)lactate production in the stomach of experimental rats.
- To determine if D(-)lactate is absorbed into the bloodstream and its isomeric status in rats.
Main Methods:
- Analysis of stomach contents from normal experimental rats.
- Bloodstream absorption studies.
- Isomer identification techniques.
Main Results:
- Significant quantities of D(-)lactate were detected in the stomach of normal experimental rats.
- D(-)Lactate was found to be absorbed into the bloodstream.
- D(-)Lactate was confirmed as a physiological isomer in this animal species.
Conclusions:
- The stomach is a site of D(-)lactate production in rats.
- D(-)Lactate contributes to the physiological isomeric composition of blood in rats.
- This finding has implications for understanding lactate metabolism and physiology in rodents.