[Cholestyramine activating effect on lipoprotein biosynthesis in the rat liver]

The cholestyramine effect on the biosynthesis of lipids and lipoproteins in the rat liver was investigated in order to elucidate the mechanisms of serum triglyceride concentration increase. Cholestyramine feeding produces an increase in the biosynthesis of neutral lipids by the liver and a considerable rise in specific radioactivity of serum free cholesterol and triglycerides. Cholestyramine intensifies the biosynthesis of apoproteins of very low density lipoproteins (VLDL), formation of lipoproteins and their secretion into the blood. Increased secretion of newly synthesized VLDL, the major component of which are triglycerides, leads to hypertriglyceridemia.