A new method for experimental study on gastric mucosal damage--changes in gastric mucosa of rat in hypoxemia

We have demonstrated development of mucosal damage in rats maintained in a hypoxic condition. The gastric lesions were observed only in the corpus ventriculi in almost all cases, and they were rated as Ul-1 erosions histopathologically. The method has proven to facilitate the induction of long-sustained, stable hypoxemia of any desired degree in animals and is concluded to be appropriate for an experimental model of ulceration designed for the study of defensive mechanisms.