Related Experiment Video
Updated: May 10, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 17, 2013
Depth of ulceration in acute colitis: correlation with outcome and clinical and radiologic features
Abstract:
The depth of colonic ulceration has been graded histologically in 40 patients treated by urgent colectomy for acute colitis. Dilatation of the colon occurred in only 2 of 16 patients with ulceration limited to the submucosa, but in 18 of 24 patients with ulceration which extended into the muscle layer. Perforation occurred in 4 of the 6 patients in whom ulceration was seen to penetrate the muscle completely; the only two deaths occurred among these 4 patients. Complications of colitis thus correlated with the depth of ulceration. The clinical, laboratory, and radiologic features just before operation have been correlated with the depth of ulceration. While there was tendency for anorexia, abdominal tenderness on palpation, fever, tachycardia, leucocytosis, and hypoproteinemia to occur more commonly as the depth of ulceration increased, no single feature or combination of these features correlated well with ulcer depth. A colonic segment exceeding 5 cm in diameter with an irregular mucosal edge, outlined by gas on a plain abdominal radiograph, correlated strongly with ulceration involving the colonic muscle.
More Related Videos
09:42Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
Published on: August 26, 2014
09:11Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
Related Concept Videos
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Peptic Ulcer Disease III: Clinical Manifestations and Complications
Inflammatory Bowel Disease II: Ulcerative Colitis
Inflammatory Bowel Disease IV: Clinical Manifestations