Related Experiment Video
Updated: Aug 7, 2026
08:20
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
Strain differences in target organ weight changes among mice treated with androgens
Growth
|March 1, 1980
Summary
Genetic differences in mouse strains significantly impact seminal vesicle and submandibular gland weights. Androgen administration confirms these weight differences, highlighting their utility for studying androgen sensitivity and hormonal pathology.
Area of Science:
- Endocrinology
- Genetics
- Animal Models
Background:
- Inbred mouse strains exhibit natural variations in reproductive organ weights.
- Androgen hormones play a critical role in the development and maintenance of male reproductive tissues.
Purpose of the Study:
- To investigate genetic influences on seminal vesicle (SV), submandibular gland (SG), and testes weights in mice.
- To assess the role of exogenous androgen in modulating these organ weights across different genetic strains.
Main Methods:
- Comparison of SV, SG, and testes weights in 26 inbred mouse strains at 100 days of age.
- Administration of varying doses of exogenous androgen to castrated mature males from representative high, medium, and low SV weight strains.
Main Results:
- Significant differences in SV, SG, and testes weights were observed among the 26 inbred mouse strains.
- Exogenous androgen administration led to dose-dependent increases in SV and SG weights, maintaining the original rank order of responsiveness across strains.
Conclusions:
- Mouse strain-specific differences in androgen sensitivity are genetically determined.
- These findings support the use of inbred mice as models for studying androgen action, hormonal regulation, and genetically influenced pathologies.
