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Related Experiment Videos

Tuberculosis therapy and enzyme induction in man

C Larousse, Y Le Normand, M F Kergueris

    International Journal of Clinical Pharmacology, Therapy, and Toxicology
    |April 1, 1980
    PubMed
    Summary

    Tuberculosis treatment with Rifampicin, Isoniazid, and Ethambutol can induce liver enzymes. Rapid acetylator patients showed a significant decrease in antipyrine half-life, indicating enzyme induction.

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    Area of Science:

    • Pharmacology
    • Hepatology
    • Clinical Biochemistry

    Background:

    • Antitubercular drugs, including Rifampicin, Isoniazid, and Ethambutol, are known to affect liver enzyme activity.
    • Individual variability in drug metabolism, particularly acetylation, can influence treatment outcomes and drug-induced effects.

    Purpose of the Study:

    • To evaluate the enzymatic inducing effect of a standard antitubercular treatment regimen.
    • To investigate the relationship between acetylator phenotype and drug-induced enzyme activity.

    Main Methods:

    • Assessed changes in urinary D-glucaric acid elimination and antipyrine half-life in 21 patients before and after two weeks of antitubercular treatment.
    • Categorized patients into slow and rapid acetylators based on isoniazid metabolism.

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    Main Results:

    • A significant increase in urinary D-glucaric acid elimination was observed in all patients after treatment.
    • Antipyrine half-life variations were not uniform; 10 patients showed a significant decrease, while 11 did not.
    • A correlation was suggested between the rapid acetylator phenotype and enzyme induction, as indicated by the antipyrine test.

    Conclusions:

    • The antitubercular treatment regimen demonstrated an enzymatic inducing effect, evidenced by increased D-glucaric acid excretion.
    • The antipyrine test revealed patient heterogeneity in response to enzyme induction, potentially linked to acetylator phenotype.
    • Rifampicin's role in enzyme induction and its interaction with acetylator status warrants further investigation.