Diuretic effect of a combined preparation of frusemide and slow-release potassium chloride

An open randomized crossover study was carried out in 10 healthy volunteers to compare the diuretic effect of a single tablet combining 40 mg frusemide and a slow-release formulation of 600 mg potassium chloride with that of the two agents given in separate tablets. The results showed that both treatments had a similar effect on urinary volume and on sodium and potassium excretion, but the hourly urinary volumes during the first 6 hours suggested that the diuretic action of the combined formulation occurred slightly earlier after administration.