Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Remyelination during optic nerve compression

R E Clifford-Jones, D N Landon, W I McDonald

    Journal of the Neurological Sciences
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A prospective study of "undiagnosed" isolated myelopathy: II. Value of magnetic resonance imaging, evoked potentials and CSF analysis.

    European journal of neurology·2013
    Same author

    Chiari-1 malformation and the neck-tongue syndrome: cause or coincidence?

    Cephalalgia : an international journal of headache·2008
    Same author

    New phenotypic diversity associated with the mitochondrial tRNA(SerUCN) gene mutation.

    Neuromuscular disorders : NMD·2005
    Same author

    Structural assessment of the urethral sphincter in women with urinary retention.

    The Journal of urology·2005
    Same author

    High field MRI correlates of myelin content and axonal density in multiple sclerosis--a post-mortem study of the spinal cord.

    Journal of neurology·2003
    Same author

    [Diagnosis of multiple sclerosis].

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2003
    Same journal

    Distinguishing drug-target effects from natural lipid variation and incorporating imaging outcomes in Mendelian randomisation studies of multiple sclerosis.

    Journal of the neurological sciences·2026
    Same journal

    Long-term social cognitive impairment after ischemic stroke: Frequency and association with lesion volume and location in an exploratory pilot study.

    Journal of the neurological sciences·2026
    Same journal

    Subjective cognitive decline among U.S. Cancer survivors, 2017-2024: Prevalence, cancer-specific patterns, and associated factors.

    Journal of the neurological sciences·2026
    Same journal

    Comment on "Comparative impact of mental and cardiovascular comorbidities on adverse outcomes in people with MS".

    Journal of the neurological sciences·2026
    Same journal

    Comment on "Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study".

    Journal of the neurological sciences·2026
    Same journal

    Increasing incidence of varicella-zoster virus meningitis in Japan, 2011-2022.

    Journal of the neurological sciences·2026
    See all related articles

    Chronic compression in cat optic nerves causes demyelination and nerve fiber degeneration. While remyelination occurs, it is incomplete and myelin thickness remains abnormal, impacting nerve function.

    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Pathology

    Background:

    • Optic nerve damage can result from sustained pressure.
    • Understanding structural changes is crucial for nerve repair research.

    Purpose of the Study:

    • To investigate the structural consequences of chronic optic nerve compression in cats.
    • To analyze the process and extent of demyelination and remyelination.

    Main Methods:

    • Light and electron microscopy were used.
    • Cats' optic nerves were subjected to incremental chronic compression.

    Main Results:

    • Extensive demyelination and Wallerian degeneration occurred within the first week.
    • Remyelination was observed after 5 weeks, persisting despite continued compression.

    Related Experiment Videos

  • However, incomplete remyelination and variable myelin thickness were noted even after 19 weeks.

    • Conclusions:

    • Chronic compression induces significant structural damage in the optic nerve.
    • While the optic nerve shows a capacity for remyelination, it is often incomplete and functionally suboptimal.
    • These findings have implications for understanding recovery after optic nerve injury.