Thorotrast-induced meningioma. Case report

Area of Science:

• Neurology
• Oncology
• Radiology

Background:

• Intracranial meningiomas are tumors arising from the meninges.
• Thorium dioxide (Thorotrast) was historically used as a contrast agent.
• Long-term complications of Thorotrast include an increased risk of various cancers.

Observation:

• A case study of an adult patient with a symptomatic intracranial meningioma.
• Diagnostic imaging included computerized tomography and angiography.
• Surgical exploration confirmed the tumor's presence.

Findings:

• The meningioma was located at a site previously treated with thorium dioxide injection.
• Pathological examination revealed thorium granules within the meningioma tissue.
• This suggests a potential link between prior Thorotrast exposure and meningioma development.

Implications:

• Highlights the potential long-term oncogenic risks associated with historical contrast agents like thorium dioxide.
• Underscores the importance of considering past medical history, including contrast agent use, in diagnosing complex neurological conditions.
• May inform future risk assessments and patient monitoring strategies for individuals with historical exposure to thorium dioxide.