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The effect of aging on complement activity (CH50) and complement protein levels

K Nagaki, S Hiramatsu, S Inai

    Journal of Clinical & Laboratory Immunology
    |January 1, 1980
    PubMed
    Summary
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    This study investigated complement system activity in aging. Older adults showed increased complement component levels (CH50, C1q, C4, C3, C5, C9) and decreased factor B, while C1 inactivator remained stable.

    Area of Science:

    • Immunology
    • Gerontology

    Background:

    • The complement system is crucial for innate immunity.
    • Age-related changes in immune function are well-documented.
    • Understanding complement system dynamics in aging is vital for health.

    Purpose of the Study:

    • To analyze age-related variations in complement system components.
    • To quantify total complement activity (CH50) and specific protein levels in different age groups.

    Main Methods:

    • Sera from 1,130 healthy individuals (20-79 years old) were analyzed.
    • Measurements included total complement activity (CH50) and protein levels of C1q, C4, C3, C5, C9, factor B, and C1 inactivator.

    Main Results:

    • Older age groups exhibited increased CH50, C1q, C4, C3, C5, and C9 levels.

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  • A decrease in factor B levels was observed in older individuals.
  • C1 inactivator levels showed minimal variation across age groups.

    • Conclusions:

    • Complement system activity undergoes significant alterations with aging.
    • Specific complement components are upregulated, while others are downregulated in older adults.
    • These findings contribute to understanding immune system changes in aging.