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Abnormal growth hormone response in obesity with normal carbohydrate tolerance and normal thyroid function
Endokrinologie
|May 1, 1978
Summary
Obese adults show abnormal growth hormone (HGH) responses to glucose and insulin challenges. Impaired HGH secretion may contribute to reduced lipolysis and fat deposition in obesity.
Area of Science:
- Endocrinology
- Metabolism
- Obesity Research
Background:
- Obesity is a complex metabolic disorder.
- Growth hormone (HGH) plays a role in lipolysis and fat metabolism.
- Understanding HGH dynamics in obesity is crucial for metabolic research.
Purpose of the Study:
- To compare growth hormone (HGH) response to glucose-induced hyperglycemia and insulin-induced hypoglycemia in obese versus normal-weight individuals.
- To investigate the relationship between HGH levels and body weight.
- To determine if abnormal HGH response is characteristic of obesity without carbohydrate intolerance or thyroid dysfunction.
Main Methods:
- Studied 13 obese adults and 16 normal-weight controls.
- Measured serum HGH levels following glucose and insulin challenges.
- Assessed carbohydrate tolerance and thyroid function.
Main Results:
- Obese subjects had significantly lower HGH levels compared to controls.
- HGH concentrations were inversely related to body weight.
- Obese individuals lacked HGH suppression during hyperglycemia and showed a blunted HGH response to insulin.
Conclusions:
- Abnormal HGH response is a characteristic feature in obese individuals with normal carbohydrate tolerance and thyroid function.
- Impaired HGH secretion may lead to diminished lipolysis and increased fat deposition in obesity.
- These findings suggest a potential link between HGH dysregulation and the pathophysiology of obesity.