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Some thoughts on evolution

R A Conyers, N L Fazzalari

    Medical Hypotheses
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    The fossil record

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    Area of Science:

    • Evolutionary biology
    • Developmental biology
    • Paleontology

    Background:

    • The fossil record presents challenges to evolutionary theory, notably the scarcity of transitional forms.
    • The abrupt appearance of higher taxa in fossils contradicts gradual evolutionary models.
    • Neo-Darwinian evolution struggles to explain these observed discontinuities.

    Purpose of the Study:

    • To propose a mechanism explaining the discontinuities in the fossil record.
    • To re-evaluate the role of mutations in evolutionary theory.
    • To reconcile cellular dynamics with macroevolutionary patterns.

    Main Methods:

    • Conceptual modeling of cellular systems as steady states.
    • Analysis of mutation effects on regulatory versus non-regulatory proteins.

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  • Extrapolation of cellular mutation effects to multicellular organisms.

    • Main Results:

    • Mutations in regulatory proteins significantly impact cellular steady states more than non-regulatory mutations.
    • These regulatory mutations, when expressed in multicellular systems, can explain species discontinuities.
    • The proposed mechanism offers an alternative to gradualism for evolutionary change.

    Conclusions:

    • Cellular regulatory mutations provide a sufficient explanation for abrupt evolutionary transitions.
    • This mechanism has significant implications for existing theories of evolution.
    • The study highlights the importance of regulatory evolution in macroevolutionary events.