Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of FcgammaRIIA cytoplasmic tail requirements in signaling for serotonin secretion: evidence for an ITAM-dependent, PI3K-dependent pathway.

Scandinavian journal of immunology·2010
Same author

The cytoplasmic domain of FcgammaRIIA (CD32) participates in phagolysosome formation.

Blood·2001
Same author

Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis.

The Journal of cell biology·2001
Same author

Indirect role for COPI in the completion of FCgamma receptor-mediated phagocytosis.

The Journal of biological chemistry·2001
Same author

Serum lipids and arterial plaque load are altered independently with high-dose progesterone in hypercholesterolemic male rabbits.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2001
Same author

Fc gamma receptors differ in their structural requirements for interaction with the tyrosine kinase Syk in the initial steps of signaling for phagocytosis.

Clinical immunology (Orlando, Fla.)·2001
Same journal

Barriers, Breakthroughs, and the Future of Pediatric Dermatologic Care.

Pediatric clinics of North America·2026
Same journal

Advancing Pediatric Dermatology: Innovations in Care and Access.

Pediatric clinics of North America·2026
Same journal

No Child Left Behind: Advancing Access in Pediatric Dermatology, a 4-Year, Single-Center Experience.

Pediatric clinics of North America·2026
Same journal

Telemedicine and Access to Pediatric Dermatology Care.

Pediatric clinics of North America·2026
Same journal

Inequitable Reimbursement for Pediatric Providers: A Review of Structural Factors that Disincentivize the Care of Children.

Pediatric clinics of North America·2026
Same journal

Medical Photography's Power to Change Medical Care.

Pediatric clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Jul 1, 2026

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
06:29

Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

Published on: January 29, 2014

Autoimmune hemolytic anemia

A D Schreiber

    Pediatric Clinics of North America
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    In autoimmune hemolytic anemia, the body mistakenly attacks its own red blood cells. This process primarily involves the liver and spleen clearing antibody-coated cells, with complement playing a role in IgM-mediated destruction.

    More Related Videos

    Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
    12:36

    Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

    Published on: June 26, 2018

    Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
    05:55

    Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

    Published on: December 1, 2023

    Related Experiment Videos

    Last Updated: Jul 1, 2026

    Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells
    06:29

    Methods for Quantitative Detection of Antibody-induced Complement Activation on Red Blood Cells

    Published on: January 29, 2014

    Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
    12:36

    Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

    Published on: June 26, 2018

    Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
    05:55

    Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis

    Published on: December 1, 2023

    Area of Science:

    • Immunology
    • Hematology
    • Pathophysiology

    Background:

    • Autoimmune hemolytic anemia (AIHA) involves autoantibodies targeting erythrocyte membrane antigens.
    • Hemolysis in AIHA is predominantly extravascular.
    • The reticuloendothelial system, particularly the liver and spleen, is crucial for clearing antibody-opsonized erythrocytes.

    Purpose of the Study:

    • To elucidate the mechanisms of erythrocyte destruction in AIHA.
    • To highlight the roles of specific organs and immune components in AIHA pathogenesis.

    Main Methods:

    • This study is a review of existing literature on AIHA.
    • Analysis of pathological mechanisms and cellular interactions involved in AIHA.

    Main Results:

    • Extravascular hemolysis is the primary mode of red blood cell destruction in AIHA.
    • The liver and spleen are key sites for the clearance of antibody-coated red blood cells.
    • Complement activation is significant in the destruction of IgM-coated cells.

    Conclusions:

    • Understanding the extravascular clearance pathways is vital for managing AIHA.
    • The interplay between autoantibodies, complement, and the reticuloendothelial system dictates disease severity in AIHA.