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Abstract:
A ten-year-old black girl with sickle cell disease developed anti-Fy5 antibody. She received one unit of Fy5 positive blood and had a delayed hemolytic transfusion reaction four days later. In addition she had anti-E, anti-C and anti-K antibodies. A clinical picture of autoimmune hemolytic anemia evolved with a strongly positive direct antiglobulin test and strong auto anti-I antibodies. She improved after a course of steroid therapy.