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Induction of colonic adenocarcinomas by 1,2-dimethylhydrazine intrarectally administered in rats
Digestion
|January 1, 1978
Abstract:
Multiple colorectal adenocarcinomas were found in Sprague-Dawley rats after intrarectal injection of 1,2-dimethylhydrazine (DMH). These lesions along with mild hyperplasia of the surrounding mucosa developed within 34 weeks after either 3 or 8 injections of 250 mg DMH/kg body weight.
