[Biochemical nature of complement-fixing antigen of arenaviruses]

G V Rezapkin, V N Bashkirtsev, E A Tkachenko

|March 1, 1980

Abstract:

Soluble antigens of 6 arenaviruses (Tacaribe, Tamiami, LCM, Amapari, Machupo, and Junin) were isolated by gel chromatography in servachromium A-2. It was shown that practically the entire antigenic activity of the original virus-containing preparations in complement-fixation (CFT) and agar gel diffuse precipitation (AGDP) tests was due to the presence of soluble antigens in them. Antigenic relationships of the isolated soluble antigens were studied. Physicochemical characteristics of the soluble antigens were determined: buoyant density in cesium chloride solution, sedimentation properties, and sensitivity to RNase. The experimental results suggest that the soluble antigens are fragments of virion nucleocapsids.

Related Concept Videos

Articles linked to this work by shared authors, journal, and citation graph.

[The rs2564978(T) Allele Associated with Severe Influenza A Disrupts the Binding Site for Myeloid Differentiation Factor PU.1 and Reduces CD55/DAF Gene Promoter Activity in Macrophages].

Molekuliarnaia biologiia·2024

[Enzyme immunoassay system for serological diagnosis of hemorrhagic fever with renal syndrome based on inactivated purified Puumala virus (Hantaviridae: Orthohantavirus)].

Voprosy virusologii·2024

Related Experiment Videos

[Biochemical nature of complement-fixing antigen of arenaviruses]

Related Concept Videos

[The rs2564978(T) Allele Associated with Severe Influenza A Disrupts the Binding Site for Myeloid Differentiation Factor PU.1 and Reduces CD55/DAF Gene Promoter Activity in Macrophages].

[Enzyme immunoassay system for serological diagnosis of hemorrhagic fever with renal syndrome based on inactivated purified Puumala virus (Hantaviridae: Orthohantavirus)].

[Full and D-Box-Deficient PTTG1 Isoforms: Effects on Cell Proliferation].

[Real-time PCR assay development for the control of vaccine against hemorrhagic fever with renal syndrome].

[Development of inactivated cultural yellow fever vaccine].

[Experience of application of IgY-technology for laboratory diagnostics of viral infections.]

[Molecular characterization of a rare rotavirus (Sedoreoviridae: Rotavirus) strain genotype G2P[9] isolated from a child with acute gastroenteritis].

[Genetic characteristics of adenoviruses (Adenoviridae: Mastadenovirus) circulating among military personnel with respiratory infections during the 2023-2024 season in the Sverdlovsk Region].

[Test systems for the laboratory detection and differentiation of Powassan virus from tick-borne encephalitis virus (Flaviviridae: Orthoflavivirus) using RT-PCR and RT-qPCR].

[Rapid differentiation of genotype I and new recombinant variant of African swine fever virus (Asfarviridae: Asfivirus) using real-time PCR].

[Influenza virus infection affects the efficacy of the treatment of dyslipidemia in mice with a polyisoprenoid-based drug].

[Serological tests based on viral glycoproteins for detecting neutralizing antibodies to measles, mumps and rubella viruses].

Related Experiment Videos

[Biochemical nature of complement-fixing antigen of arenaviruses]

Abstract:

Related Concept Videos

Related Articles