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Red-cell 2,3-diphosphoglycerate in patients with hyperthryoidism
Acta Endocrinologica
|April 1, 1980
Summary
Hyperthyroid patients exhibit elevated red blood cell 2,3-diphosphoglycerate (2,3-DPG) levels, impacting oxygen transport. Treatment normalizes these levels, suggesting a link between thyroid hormones and 2,3-DPG.
Area of Science:
- Endocrinology
- Hematology
- Physiology
Background:
- Hyperthyroidism is associated with altered oxygen transport.
- Red blood cell 2,3-diphosphoglycerate (2,3-DPG) influences hemoglobin's oxygen affinity.
Purpose of the Study:
- To investigate red blood cell 2,3-DPG levels in hyperthyroid patients.
- To determine the relationship between thyroid hormones and 2,3-DPG.
- To assess the impact of hyperthyroidism treatment on 2,3-DPG.
Main Methods:
- Measured red blood cell 2,3-DPG in 21 hyperthyroid females and compared to euthyroid controls.
- Assessed correlations between serum thyroid hormones and 2,3-DPG.
- Re-evaluated 2,3-DPG levels in 8 patients after thyroid function normalization.
Main Results:
- Hyperthyroid patients showed significantly higher 2,3-DPG levels (5.75 mM) than controls (4.88 mM).
- A positive correlation was observed between serum thyroid hormones and 2,3-DPG concentration.
- Post-treatment, 2,3-DPG levels normalized (4.81 mM) without changes in hematocrit, hemoglobin, or phosphataemia.
Conclusions:
- Elevated red blood cell 2,3-DPG is a characteristic finding in hyperthyroidism.
- Thyroid hormones directly influence 2,3-DPG levels.
- Increased 2,3-DPG may contribute to the rightward shift of the oxygen dissociation curve in hyperthyroidism.