Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mydriasis from topically administered phenylephrine HCl powder

C N Thornton, C Hanna

    American Journal of Ophthalmology
    |June 1, 1980
    PubMed
    Summary

    Powdered phenylephrine HCl delivered microgram amounts to the eye, achieving useful pupil dilation with a single 50-microgram dose. This method offers an effective alternative to traditional eye drops for mydriasis.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Black Hole Spectroscopy and Tests of General Relativity with GW250114.

    Physical review letters·2026
    Same author

    GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

    Physical review letters·2025
    Same author

    Search for Subsolar-Mass Binaries in the First Half of Advanced LIGO's and Advanced Virgo's Third Observing Run.

    Physical review letters·2022
    Same author

    109 Utilising cell-free DNA for detection of gene editing outcomes in rhesus macaque embryos.

    Reproduction, fertility, and development·2022
    Same author

    Constraints on Cosmic Strings Using Data from the Third Advanced LIGO-Virgo Observing Run.

    Physical review letters·2021
    Same author

    Launch of the National Rectal Cancer Intensity-Modulated Radiotherapy Guidance.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2020

    Area of Science:

    • Ophthalmology
    • Pharmacology
    • Drug Delivery Systems

    Background:

    • Traditional ophthalmic drug delivery often involves liquid solutions or suspensions.
    • Achieving precise and effective ocular drug concentrations can be challenging with conventional methods.
    • Exploring novel drug delivery systems is crucial for improving therapeutic outcomes in ophthalmology.

    Purpose of the Study:

    • To evaluate the efficacy of microgram amounts of powdered phenylephrine hydrochloride (HCl) for inducing mydriasis (pupil dilation).
    • To compare the mydriatic effect of powdered phenylephrine HCl with conventional phenylephrine HCl eye drops.
    • To investigate the potential of powdered drug formulations for delivering nonirritating microgram quantities of ophthalmic agents.

    Main Methods:

    • Administration of finely powdered phenylephrine HCl in microgram quantities to the conjunctiva of human volunteers.
    • Construction of dose-response and time-response curves for phenylephrine HCl powder.
    • Comparison of the effects of powdered phenylephrine HCl with standard 10% phenylephrine HCl drops.
    • Administration of powdered pilocarpine HCl to assess miosis induction.

    Main Results:

    • A threshold mydriasis was observed with less than 5 micrograms of phenylephrine HCl powder in white subjects.
    • A clinically useful mydriasis was achieved with a single 50-microgram application of phenylephrine HCl powder.
    • The mydriatic effect of 50 micrograms of powdered phenylephrine HCl was comparable to three applications of 10% phenylephrine HCl drops.
    • Twenty-five micrograms of powdered pilocarpine HCl induced significant miosis (pupil constriction).

    Conclusions:

    • Microgram powdered phenylephrine HCl is an effective agent for inducing clinically useful mydriasis.
    • This powdered formulation offers a potentially more potent and longer-lasting effect compared to traditional phenylephrine HCl eye drops.
    • The study demonstrates the feasibility of delivering nonirritating microgram amounts of powdered ophthalmic drugs, including phenylephrine HCl, pilocarpine HCl, and fluorescein.

    Related Experiment Videos