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Leucogenenol a thymothyroid hormone

F A Rice, J D McCurdy, C Oresajo

The American Journal of Physiology

|June 1, 1980

Summary

This summary is machine-generated.

The thymus and thyroid are key to producing leucogenenol, a substance vital for maintaining normal white blood cell counts in animals. Thymus removal significantly lowers leucogenenol levels.

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Area of Science:

Immunology
Endocrinology
Biochemistry

Background:

Leucogenenol is a substance found in animal circulation.
The thymus and thyroid are endocrine glands with known roles in immune and metabolic functions.

Purpose of the Study:

To investigate the role of the thymus and thyroid in the biosynthesis of leucogenenol.
To determine the effect of thymectomy and thyroidectomy on serum leucogenenol levels.

Main Methods:

Surgical thymectomy and thyroidectomy were performed on rats.
Leucogenenol levels in serum were measured.
Neonatally thymectomized mice were injected with leucogenenol.
Radioactive D-glucose was used to trace leucogenenol biosynthesis in thymus and thyroid tissues.

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Main Results:

Thymectomy and thyroidectomy significantly decreased serum leucogenenol levels in rats.
Leucogenenol injections in thymectomized mice maintained normal neutrophil and lymphocyte circulation.
The thymus and thyroid were identified as the sole tissues capable of synthesizing radioactive leucogenenol from D-glucose.

Conclusions:

The thymus gland plays a crucial role in the biosynthesis of leucogenenol.
The thyroid gland may also contribute to leucogenenol biosynthesis.
Leucogenenol is essential for maintaining normal circulating levels of neutrophils and lymphocytes.