[Clinical manifestations and the ways to prevent antibiotic allergy in nonspecific pulmonary pathology]

Retrospective analysis of 555 cases with nonspecific pulmonary pathology was performed. Certain allergic reactions to antibiotics were revealed in 172 (30.8%) patients, while the physicians recorded such reactions only in 65 (11.7%) patients. Allergy to 2 or more drugs was more frequent. Antibiotic intolerance was mainly evident from the temperature increase (44%), skin eruption (22%), development or aggravation of the bronchospastic syndrome (12.2%), Quincke's edema (69%), blood eosinophilia (6.9%) and sometimes other reactions. The bronchospastic syndrome was largely observed in patients treated with antibiotic inhalations. Clinical manifestations of antibiotic allergy were concomitant in most cases. The temperature increase, skin eruptions and blood eosinophilia may be considered as the early manifestations of the allergy, while impairment of the bronchial patency as the late manifestation. Intolerance of antibiotics significantly lowers their efficiency. Rational use of antibiotics, due regard for the history of allergic reactions and in vitro tests for antibiotic susceptibility are important measures in prevention of allergic reactions to antibiotics.