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Updated: Aug 4, 2026
05:59
Reproducable Paraplegia by Thoracic Aortic Occlusion in a Murine Model of Spinal Cord Ischemia-reperfusion
Published on: March 3, 2014
Spinal cord compression with paraplegia in myelofibrosis
Archives of Neurology
|June 1, 1980
Summary
Paraplegia developed in a patient due to extramedullary hematopoiesis, a complication of polycythemia rubra vera and myelofibrosis. Early diagnosis and aggressive treatment are crucial to prevent permanent paralysis.
Area of Science:
- Hematology
- Neurology
- Oncology
Background:
- Polycythemia rubra vera (PRV) is a myeloproliferative neoplasm.
- Myelofibrosis is a serious bone marrow disorder.
- Extramedullary hematopoiesis (EMH) involves blood cell production outside the bone marrow.
Observation:
- A 70-year-old male patient with a 15-year history of PRV and a 2-year history of myelofibrosis developed paraplegia.
- The paraplegia was caused by extensive epidural involvement from EMH.
Findings:
- EMH can lead to significant neurological complications.
- Epidural EMH can cause spinal cord compression and permanent paralysis.
Implications:
- Prompt diagnosis of spinal cord compression in patients with PRV and myelofibrosis is critical.
- Aggressive therapeutic interventions are necessary to manage EMH complications.
- Timely treatment can potentially prevent irreversible neurological deficits.
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