Agenesis of the corpus callosum

A father and son with agenesis of the corpus callosum are described. An 11-year-old boy underwent clinical examination because of poor school performance. On physical and mental examinations he was normal, except for an enlarged head. Computerized tomographic (CT) scan showed agenesis of the corpus callosum. The patient's father also had an enlarged head. Although he had never had any symptoms, he underwent CT scanning, which revealed agenesis of the corpus callosum. Psychological tests showed good communication between the two cerebral hemispheres. All-night sleep EEGs showed asynchronous sleep spindles.