Calcium-induced calcium release in sarcoplasmic reticulum vesicles purified from rabbit fast skeletal muscle

Addition of small amounts of CaCl2 can induce calcium release from calcium-filled sarcoplasmic reticulum vesicles. The time of onset and rate of calcium release in the vesicular preparations, which occurs when ionized Ca2+ in the medium is increased from less than 1 microM to 3-5 microM, are considerably slower than in skinned muscle fiber preparations.