Pharmacological activity of new derivatives of morphine

Three new derivatives of morphine: O3-(beta-isopropylaminoethyl) ether of morphine (T .3289), O3, O6-[N,N'-bis(methylcarbamate] ester of morphine (T .3298) and beta-dimethylamino-ethyl-ether of dihydromorphinone (T .3403) were tested for their action on CNS. A detailed study of pain threshold, motor activity, conditioned behavior and noradrenaline levels in brain was carried out. The compounds T .3289 and T .3298 exhibited analgesic action. The spontaneous activity of rats was decreased by T .3289 and increased by T .3298. The conditioned avoidance response was decreased and the brain nor-adrenaline levels were altered.