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Carnitine acetyltransferase in developing mammals

D W Seccombe, P Hahn

    Biology of the Neonate
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Mitochondrial carnitine acetyltransferase (CAT) activity increases during development in rat liver and brown fat. This mitochondrial enzyme, unlike the microsomal form, is likely involved in fatty acid oxidation.

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    Area of Science:

    • Biochemistry
    • Developmental Biology
    • Metabolism

    Background:

    • Carnitine acetyltransferase (CAT) plays a role in energy metabolism.
    • Understanding CAT activity during development is crucial for insights into metabolic adaptations.

    Purpose of the Study:

    • To investigate the developmental changes in carnitine acetyltransferase (CAT) activity in rat, rabbit, and guinea pig liver and brown adipose tissue.
    • To differentiate the roles of mitochondrial and microsomal CAT in fatty acid oxidation.

    Main Methods:

    • Assessed mitochondrial and microsomal carnitine acetyltransferase (CAT) activity.
    • Measured catalase activity as a peroxisomal marker.
    • Compared enzyme activities in liver and brown adipose tissue across different developmental stages and species.

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    Main Results:

    • Mitochondrial CAT activity increased perinatally in rat liver and brown adipose tissue, with higher absolute levels in brown fat.
    • Microsomal CAT activity increased in rat brown adipose tissue and liver postnatally.
    • Hepatic mitochondrial CAT activity was significantly higher prenatally in guinea pigs and rabbits compared to rats.

    Conclusions:

    • Mitochondrial carnitine acetyltransferase (CAT) is likely directly involved in fatty acid oxidation.
    • The function of microsomal CAT remains unclear.
    • Species-specific differences in hepatic mitochondrial CAT activity exist during development.