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Related Experiment Videos

[Macrophage activation by blastolysin]

I B Sorokina, E L Khasman, N P Gor'kova

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |April 1, 1980
    PubMed
    Summary
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    [Isolation and structure of the active component of the antitumor agent blastolysin].

    Bioorganicheskaia khimiia·1987

    Blastolysin, derived from Lactobacillus bulgaricus, demonstrates significant antineoplastic activity and activates immune cells. This immunotherapy agent shows a two-phasic effect on macrophage-induced cytotoxicity against tumors.

    Area of Science:

    • Immunology
    • Oncology
    • Microbiology

    Background:

    • Blastolysin, a glycopeptide from Lactobacillus bulgaricus cell walls, exhibits antineoplastic properties.
    • The immune system, particularly the mononuclear phagocytic system, plays a crucial role in tumor surveillance and elimination.

    Purpose of the Study:

    • To investigate the antineoplastic activity of Blastolysin.
    • To elucidate the mechanism of Blastolysin-induced immune activation, focusing on macrophage function.

    Main Methods:

    • Administration of Blastolysin to animals with transplanted and spontaneous tumors.
    • Assessment of macrophage phagocytosis, digestion, and cytotoxic activity against tumor cells (using chromium-51 labeling).
    • Comparison of Blastolysin with Bacillus Calmette-Guerin (BCG) in modulating macrophage cytotoxicity.

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    Main Results:

    • Blastolysin demonstrated significant antineoplastic activity against various animal tumors.
    • Blastolysin stimulated phagocytosis and digestion by macrophages.
    • Macrophage-induced cytotoxicity against tumor cells exhibited a distinct two-phasic pattern following Blastolysin administration: an early transient phase and a later, sustained phase.

    Conclusions:

    • Blastolysin possesses potent antineoplastic and immunomodulatory effects.
    • The observed two-phasic macrophage activation suggests a complex immune response mechanism.
    • Blastolysin represents a promising candidate for cancer immunotherapy, potentially enhancing the host's anti-tumor immune response.