Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Early pregnancy interruption with two 15-ME-PGF2a suppositories

N H Lauersen, K H Wilson

    Contraception
    |March 1, 1980
    PubMed
    Summary

    A two-suppository regimen using 15-methyl prostaglandin F2a (15-ME-PGF2a) effectively terminated early pregnancies. This method offers a potential non-surgical alternative for pregnancy termination.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Adenoviral gene transfer to the heart during cardiopulmonary bypass: effect of myocardial protection technique on transgene expression.

    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery·2002
    Same author

    Cardiac gene delivery with cardiopulmonary bypass.

    Circulation·2001
    Same author

    Adenovirus-mediated genetic manipulation of the myocardial beta-adrenergic signaling system in transplanted hearts.

    The Journal of thoracic and cardiovascular surgery·2000
    Same author

    Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery.

    The Journal of clinical investigation·1999
    Same author

    Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli.

    Infection and immunity·1999
    Same author

    Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats.

    Gastroenterology·1999

    Area of Science:

    • Reproductive Medicine
    • Pharmacology
    • Obstetrics & Gynecology

    Background:

    • Early pregnancy termination often involves surgical procedures.
    • Pharmacological methods are being explored as alternatives.
    • Prostaglandins have demonstrated abortifacient properties.

    Purpose of the Study:

    • To evaluate the efficacy of vaginal 15-methyl prostaglandin F2a (15-ME-PGF2a) suppositories for early pregnancy termination.
    • To compare a single-dose regimen with a two-suppository regimen.

    Main Methods:

    • Vaginal administration of 15-ME-PGF2a suppositories (3-mg single or 1-mg followed by 3-mg).
    • Pregnancy status assessed by pregnancy tests at 14 days post-insertion.
    • Uterine activity, bleeding, and side effects monitored.

    Main Results:

    • 34 of 39 patients (87%) achieved pregnancy termination with the two-suppository regimen.
    • The two-suppository regimen showed higher success rates and faster onset of action.
    • Reduced gastrointestinal side effects and more consistent plasma levels observed with the two-suppository approach.

    Conclusions:

    • A two-suppository regimen of 15-ME-PGF2a is an effective method for early pregnancy termination.
    • This regimen presents a promising non-surgical, pharmacologic alternative.
    • Further studies are warranted to establish its outpatient practicality.

    Related Experiment Videos