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[Immunosuppressive effect of lysosomal factors in the liver (author's transl)]

H Bockhorn, G E Schrempf-Decker, D P Baron

    Chirurgisches Forum Fur Experimentelle Und Klinische Forschung
    |January 1, 1980
    PubMed

    A lysosomal factor isolated from liver tissue (LF) reveals a strong suppressive effect on the in vitro immune response. LF is not species specific and is able to act specifically on the responder function of mitogen or alloantigen-mediated lymphocyte proliferation. The peculiar immunological feature of the liver that it induces a pronounced immunological hyporeactivity can be explained by a similar effect of LF on the cellular immune response in vivo which leads to a reduced rejection of the allotransplanted organ.

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