New aspects in the pathogenesis of gastric ulcer

1) One of the possible etiologies of gastric ulcers which frequently occur in the lesser curvature is ischemia or necrosis of the gastric wall, which stem from increased rigidity of the blood vessel walls, mainly caused by dysfunction of sympathetic nerve. 2) The main blood supply to the gastric wall is controlled by gastric arteries, with the gastroepiploic arteries playing only an auxiliary role. 3) It should be noted that gastric bleeding or mucosa necrosis will occasionally occur in some cases of SPV or SV. 4) It was established that experimental rat ulcers of UL-II or UL-III severity which are analogous to human gastric ulcer are produced by cold restricted rat combined with ligation of the gastric arteries (MOHRI's method).