[Electroencephalographic changes under the influence of drug substances that induce narcomania]

The authors carried out studies on 57 cats, made unmovable by curare and to whom under the conditions of acute experiment electrodes were introduced in the amygdala, hypothalamus, septum, mesencephalic reticular formation and cerebral cortex by means of a stereotaxic apparatus. Bioelectric activity from these structures was recorded by a polyphysiograph Hellige. The effect of alcohol, morphine, phenobarbital, diasepam, chlorpromasine, amphetamine and LSD was examined. All examined substances except chlropromasine induced excitation in amygdala, hypothalamus and septum. Morphine phenobarbital and diasepam inhibited mesencephalic reticular formation, but amphetamine and LSD-excitation. Chlorpromasine caused inhibition in all structures. On the basis of literary data that structures are included in the so called "rewarding system" the authors assume that drugs with narcotic effect induce excitation in this system in spite of their action on the cerebral cortex.