[Polyamine formation and development of functional hypertrophy in skeletal muscles with increased activity]

Cycloheximide caused no changes in activation of arginase and ornitine-sigma-ketoglutarate transaminase during loads, but the activation of ornitine decarboxylase and putrescine and polyamines production was sharply reduced. Physical load caused a significantly lower activation of enzymes of ornitine metabolism and a smaller production of polyamines in muscles of trained animals. The extent of polyamines synthesis is positively correlated with the magnitude of muscles work hypertrophy.