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Related Experiment Videos

Urate excretion in old age

A Stavroulaki-Tsapara, P Papanayiotou, A S Dontas

    Gerontology
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Elderly men have higher serum urate than women. Bacteriuria lowers urate levels, especially in men, and differs from p-aminohippurate secretion.

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    Area of Science:

    • Nephrology
    • Gerontology
    • Urology

    Background:

    • Serum urate levels exhibit sex-based differences, with elderly women generally having lower levels than men.
    • The impact of bacteriuria on serum urate and renal urate handling in the elderly requires further investigation.

    Purpose of the Study:

    • To investigate the relationship between bacteriuria, sex, and serum urate levels in elderly individuals.
    • To examine the effects of bacteriuria on renal urate and p-aminohippurate (TMPAH) clearance.
    • To assess the influence of dietary protein intake on serum urate levels.

    Main Methods:

    • Comparison of serum urate levels between nonbacteriuric and bacteriuric elderly men and women.
    • Measurement of renal urate clearance (CUrate), creatinine clearance (CCreat), and TMPAH clearance.

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  • Analysis of the ratio of urate clearance to creatinine clearance (CUrate:CIn).

    • Main Results:

    • Nonbacteriuric elderly men had higher serum urate than nonbacteriuric women.
    • Bacteriuric subjects of both sexes had lower serum urate levels compared to nonbacteriuric individuals.
    • Bacteriuria significantly reduced renal urate and TMPAH clearance in men but not in women.
    • The CUrate:CIn ratio was elevated in bacteriuric men and all women, irrespective of bacteriuria status.
    • Increased dietary protein intake correlated with higher serum urate levels.

    Conclusions:

    • Elderly women maintain lower serum urate levels, associated with higher fractional urate excretion.
    • Bacteriuria exacerbates urate retention, particularly in men, by increasing the CUrate:CIn ratio.
    • Renal urate and TMPAH secretory mechanisms differ in humans.
    • Dietary protein intake significantly influences serum urate levels, potentially masking the effects of bacteriuria.