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Related Experiment Videos

Human placental beta-endorphin

F Fraioli, A R Genazzani

    Gynecologic and Obstetric Investigation
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Human placental powder (PP) contains corticotrophin-like and beta-endorphin (beta-EP)-like substances. These beta-EP-like compounds in PP exhibit opiate activity, similar to synthetic beta-EP.

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    Area of Science:

    • Endocrinology
    • Neuroscience
    • Biochemistry

    Background:

    • Human placental powder (PP) is known to possess biological activities.
    • Corticotropin-like and beta-endorphin (beta-EP)-like activities have been suggested in PP.

    Purpose of the Study:

    • To characterize the beta-endorphin (beta-EP)-like activity in human placental powder (PP).
    • To assess the opiate activity of beta-EP-like substances found in PP.

    Main Methods:

    • Radioimmunoassay for beta-endorphin (beta-EP) quantification.
    • Sephadex G-75 gel filtration and high-pressure liquid chromatography (HPLC) for activity localization.
    • Radioreceptor assay to evaluate opiate receptor binding.

    Main Results:

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    • PP demonstrated a beta-EP potency of 4.82 ng/mg protein.
    • Beta-EP-like activity in PP co-eluted with standard beta-EP in gel filtration and HPLC.
    • PP showed a parallel dilution curve to synthetic beta-EP in a radioreceptor assay, indicating opiate activity.

    Conclusions:

    • Human placental powder (PP) contains substances with beta-endorphin (beta-EP)-like activity.
    • These beta-EP-like compounds in PP exhibit genuine opiate receptor binding activity.