Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Colitis associated with metronidazole therapy

R Saginur, C R Hawley, J G Bartlett

    The Journal of Infectious Diseases
    |June 1, 1980
    PubMed
    Summary

    Metronidazole, used for trichomonal vaginitis, caused persistent diarrhea due to Clostridium difficile infection. This highlights the risk of metronidazole-induced colitis, even when the drug is prescribed for other conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Joint analysis of BICEP2/keck array and Planck Data.

    Physical review letters·2015
    Same author

    Rapid identification of Clostridium botulinum colonies by in vitro toxicity and antimicrobial susceptibility testing.

    World journal of microbiology & biotechnology·2014
    Same author

    Clostridium difficile infection.

    Current problems in surgery·2013
    Same author

    Prospective, randomized comparison of intravenous and oral ciprofloxacin with intravenous ceftazidime in the treatment of nosocomial pneumonia.

    The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses·2012
    Same author

    Science, cynicism and scarcity.

    The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses·2012
    Same author

    Whipple's disease with constrictive pericarditis: a rare disease with a rare presentation.

    The Canadian journal of cardiology·2009

    Area of Science:

    • Microbiology
    • Clinical Medicine
    • Pharmacology

    Background:

    • Metronidazole is a common antibiotic used to treat various infections, including trichomonal vaginitis.
    • Antibiotic-associated colitis is a known complication of antimicrobial therapy.

    Observation:

    • A patient treated with metronidazole for trichomonal vaginitis developed prolonged diarrhea.
    • Stool analysis revealed a cytopathic toxin neutralized by Clostridium sordellii antitoxin.
    • Clostridium difficile was isolated from stool samples and produced a similar cytotoxin.

    Findings:

    • The isolated Clostridium difficile strain was sensitive to metronidazole in vitro.
    • This case presents a paradoxical situation where the therapeutic agent may also be the causative agent of colitis.

    Implications:

    • Metronidazole can precipitate Clostridium difficile infection, leading to antibiotic-associated colitis.
    • Clinicians should consider C. difficile as a potential cause of diarrhea in patients treated with metronidazole.
    • Further research is needed to understand the mechanisms underlying metronidazole-induced C. difficile colitis.

    Related Experiment Videos