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Menopausal changes in calcium balance performance

R P Heaney, R R Recker, P D Saville

    The Journal of Laboratory and Clinical Medicine
    |December 1, 1978
    PubMed
    Summary
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    Menopause significantly impacts calcium balance, decreasing absorption and increasing urinary excretion. Estrogen therapy in postmenopausal women restores calcium balance to premenopausal levels, highlighting estrogen

    Area of Science:

    • Endocrinology
    • Bone Metabolism
    • Reproductive Health

    Background:

    • Calcium balance is crucial for bone health and is influenced by dietary intake, absorption, and excretion.
    • Menopause is associated with hormonal changes, particularly decreased estrogen levels, which may affect calcium homeostasis.
    • Previous research indicates a correlation between calcium balance and both intake and absorption.

    Purpose of the Study:

    • To investigate the effect of menopausal status and estrogen therapy on calcium balance in women.
    • To compare calcium balance, absorption, and urinary excretion between premenopausal, postmenopausal, and estrogen-treated postmenopausal women.
    • To determine the calcium intake requirement for maintaining zero balance in different menopausal and hormonal states.

    Main Methods:

    Related Experiment Videos

    • Calcium balance was measured in 168 normal perimenopausal women across 274 studies.
    • Participants were grouped based on menopausal status (premenopausal, postmenopausal) and estrogen therapy.
    • Calcium intake, absorption, and urinary excretion were assessed to calculate calcium balance and requirement for zero balance.

    Main Results:

    • Postmenopausal women not receiving estrogen had significantly lower calcium balance (-0.043 gm/day) compared to premenopausal women (-0.0199 gm/day).
    • This difference was attributed to decreased calcium absorption and increased urinary excretion in untreated postmenopausal women.
    • Estrogen therapy in postmenopausal women normalized calcium balance and reduced the calcium intake requirement to levels similar to premenopausal women.

    Conclusions:

    • Estrogen plays a significant role in maintaining calcium balance across menopause.
    • Estrogen enhances intestinal calcium absorption and improves renal calcium conservation, thereby reducing calcium requirements.
    • Estrogen therapy can effectively mitigate the negative calcium balance associated with menopause.